Describe the two main pathways for repairing double-strand breaks and their key differences.

Describe the two main pathways for repairing double-strand breaks and their key differences.

• A. Homologous recombination uses a sister chromatid as a template for accurate repair; non-homologous end joining directly ligates ends and can be error-prone.
• B. Non-homologous end joining uses a sister chromatid as a template for accurate repair; homologous recombination ligates ends directly and is error-prone.
• C. Both pathways require a fully intact chromatid as a template.
• D. Only occurs in germ cells.

Answer: (A)